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KMID : 0363420190330030103
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Journal of Korean Oriental Pediatrics
2019 Volume.33 No. 3 p.103 ~ p.111
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Study of The Correlation of Lung-Large intestine-Skin by Ulcerative Colitis-Induced 3 Weeks Old Mice
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Ahn Sang-Hyun
Kim Ki-Bong
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Abstract
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Objectives: The purpose of this study is to understand the correlations between lung, large intestine, and skin of 3-week-old mice in which ulcerative colitis was induced, up on administration of Coptidis rhizome and Glycyrrhiza uralensis mixed extract.
Methods: Mice were divided into 4 groups as follows; no treatment group (Ctrl group), ulcerative colitis-induced mice group (UE group), ulcerative colitis-induced mice group after administering Pentasa (PT group), ulcerative colitis-induced mice group after administering Coptidis rhizoma and Glycyrrhiza uralensis mixed extract (CGT group). Mice were induced ulcerative colitis by Dextran sulfate sodium (DSS). After 5 days of administration, We obvserved anti-inflammatory effect, alveolar formation, and skin barrier control in the colon mucosa.
Results: The CGT group was observed arrangement of normal intestinal cells, Infiltration of less inflammatory cells. The CGT significantly decreased positive rseponse of TNF-α, p-IkB, Caspase 3 in large intestine, and significantly increased positive rseponse of EGF, IGF, catalase, Filaggrin, involucrin, loricrin.
Conclusions: The results of this study show the correlation of Lung-Large intestine-Skin by administering Coptidis rhizoma and Glycyrrhiza uralensis mixed extract to ulcerative colitis-induced mice.
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KEYWORD
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Coptidis rhizoma, Glycyrrhiza uralensis, Ulcerative colitis, Lung, Large intestine, Skin
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